{"id":146,"date":"2012-12-07T19:49:59","date_gmt":"2012-12-07T19:49:59","guid":{"rendered":"http:\/\/www.studyorgo.com\/blog\/?p=146"},"modified":"2014-02-21T03:22:23","modified_gmt":"2014-02-21T03:22:23","slug":"epoxide-opening-with-acids-bases-and-grignards","status":"publish","type":"post","link":"https:\/\/www.studyorgo.com\/blog\/epoxide-opening-with-acids-bases-and-grignards\/","title":{"rendered":"Epoxide Opening with Acids, Bases and Grignards"},"content":{"rendered":"<p>We here at StudyOrgo.com think it is very important to help students make connections when <a href=\"http:\/\/www.studyorgo.com\">studying organic chemistry<\/a>. When professors teach you about reactions, or you read a textbook about isolated reactions, one rarely picks up the underlying connection between related reactions. One reason that professors do not teach you these things is because it becomes a highly-testable concept that you have to &#8220;figure out on your own.&#8221; One of our main goals is to identify key connections and present them for you throughout our materials.<\/p>\n<p>Take, the opening of an epoxide as an example. The reagent will attack an epoxide at varying parts of the substance depending on the type of reagent. For example, acids attack the most substituted position on the epoxide, bases attack the least substituted position and grignards also attack the least substituted position.<\/p>\n<p>So here it is in plain, simple English:<\/p>\n<ul>\n<li><strong>Acid\u00a0<\/strong>catalyzed epoxide ring opening: attack the\u00a0<strong>most substituted<\/strong>\u00a0position on the epoxide.<\/li>\n<li><strong>Base<\/strong>\u00a0catalyzed epoxide ring opening: attack the\u00a0<strong>least substituted<\/strong>\u00a0position on the epoxide.<\/li>\n<li><strong>Grignard<\/strong>\u00a0epoxide opening:\u00a0attack the\u00a0<strong>least substituted<\/strong>\u00a0position on the epoxide<\/li>\n<\/ul>\n<p>To review these key concepts with reaction examples, visit our reaction flashcard &#8220;Study Mode&#8221; (members only) which can be accessed from the <a href=\"http:\/\/www.studyorgo.com\/my-account.php\">account homepage.<\/a><\/p>\n<p>Try:<\/p>\n<p>1) Epoxides category- Epoxide Opening Reactions (7 reactions)<\/p>\n<p>2) Alcohols category &#8211; Grignard Epoxide Opening Reaction<\/p>\n<p>Then <strong>practice<\/strong> by creating <strong>your<\/strong> <strong>own<\/strong> <strong>custom quizzes<\/strong> by visiting our<a href=\"http:\/\/www.studyorgo.com\/quiz.php\"> &#8220;Quiz Mode&#8221; homepage <\/a>(members only also).<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We here at StudyOrgo.com think it is very important to help students make connections when studying organic chemistry. When professors teach you about reactions, or you read a textbook about isolated reactions, one rarely picks up the underlying connection between related reactions. One reason that professors do not teach you these things is because it [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-146","post","type-post","status-publish","format-standard","hentry","category-organic-chemistry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/posts\/146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/comments?post=146"}],"version-history":[{"count":5,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/posts\/146\/revisions"}],"predecessor-version":[{"id":384,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/posts\/146\/revisions\/384"}],"wp:attachment":[{"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/media?parent=146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/categories?post=146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/tags?post=146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}