{"id":51,"date":"2012-07-10T16:13:46","date_gmt":"2012-07-10T16:13:46","guid":{"rendered":"http:\/\/www.studyorgo.com\/blog\/?p=51"},"modified":"2014-02-21T03:22:47","modified_gmt":"2014-02-21T03:22:47","slug":"what-is-a-good-leaving-group","status":"publish","type":"post","link":"https:\/\/www.studyorgo.com\/blog\/what-is-a-good-leaving-group\/","title":{"rendered":"What is a good &#8220;leaving group?&#8221;"},"content":{"rendered":"<p>In organic chemistry we use the term leaving group to refer to a portion of a reactant that will depart the rest of the molecule as a result of reacting with another reagent. This occurs often in organic chemistry reactions. Notably in substitution and elimination reactions.<\/p>\n<p>For example in the following SN2 reaction:<br \/>\nCH3CH2Br + \u00afOH\/DMF\u00a0\u2192 CH3CH2OH<br \/>\nThe leaving group is the Br. This is easy to notice because it has &#8220;left&#8221; the main reactant: CH3CH2Br\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0 \u00a0 \u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Now OH is in the place of the Br hence this is a substitution reaction.<\/p>\n<p>Common questions and answers:<\/p>\n<p>#1<br \/>\nSo what makes a good leaving group &#8220;good&#8221;?<br \/>\nAnswer: weak bases make good leaving groups<\/p>\n<p>#2<br \/>\nWhat are some examples of good leaving groups?<br \/>\nAnswer:<br \/>\n-OTS (tosylate)<br \/>\n-I<br \/>\n-Br<br \/>\n-Cl<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In organic chemistry we use the term leaving group to refer to a portion of a reactant that will depart the rest of the molecule as a result of reacting with another reagent. This occurs often in organic chemistry reactions. Notably in substitution and elimination reactions. For example in the following SN2 reaction: CH3CH2Br + [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/posts\/51"}],"collection":[{"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/comments?post=51"}],"version-history":[{"count":14,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/posts\/51\/revisions"}],"predecessor-version":[{"id":394,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/posts\/51\/revisions\/394"}],"wp:attachment":[{"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/media?parent=51"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/categories?post=51"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.studyorgo.com\/blog\/wp-json\/wp\/v2\/tags?post=51"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}